[HTML][HTML] Current understanding of asthma pathogenesis and biomarkers

N Habib, MA Pasha, DD Tang - Cells, 2022 - mdpi.com
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …

[HTML][HTML] Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Management of severe asthma: a European respiratory society/American thoracic society guideline

F Holguin, JC Cardet, KF Chung, S Diver… - European respiratory …, 2020 - Eur Respiratory Soc
This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to …

EAACI Biologicals Guidelines—Recommendations for severe asthma

I Agache, CA Akdis, M Akdis, GW Canonica, T Casale… - Allergy, 2021 - Wiley Online Library
Severe asthma imposes a significant burden on patients, families and healthcare systems.
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

KF Chung, SE Wenzel, JL Brozek… - European respiratory …, 2014 - Eur Respiratory Soc
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …

[HTML][HTML] The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple …

K Rejeski, DK Hansen, R Bansal, P Sesques… - Journal of Hematology & …, 2023 - Springer
Abstract Background BCMA-directed CAR T-cell therapy (CAR-T) has altered the treatment
landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side …

Pathogenesis of rhinitis

AO Eifan, SR Durham - Clinical & Experimental Allergy, 2016 - Wiley Online Library
Rhinitis is a heterogeneous condition that has been associated with inflammatory responses
as in allergic rhinitis but can also occur in the absence of inflammation such as in so‐called …

Advances in understanding and reducing the burden of severe asthma in children

MW Pijnenburg, L Fleming - The Lancet Respiratory Medicine, 2020 - thelancet.com
Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …

International consensus on (ICON) pediatric asthma

NG Papadopoulos, H Arakawa, KH Carlsen… - Allergy, 2012 - Wiley Online Library
Asthma is the most common chronic lower respiratory disease in childhood throughout the
world. Several guidelines and/or consensus documents are available to support medical …

[HTML][HTML] Pathology of asthma

M Kudo, Y Ishigatsubo, I Aoki - Frontiers in microbiology, 2013 - frontiersin.org
Asthma is a serious health and socioeconomic issue all over the world, affecting more than
300 million individuals. The disease is considered as an inflammatory disease in the airway …