Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Therapeutic cells encapsulated in immunobarrier devices have promise for treatment of a
variety of human diseases without immunosuppression. The absence of sufficient oxygen …

Clinically, many candidates for islet transplantation are already immunized, which increases
their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device …

Islet transplantation represents a potential cure for type 1 diabetes, yet the clinical approach
of intrahepatic delivery is limited by the microenvironment. Microporous scaffolds enable …

Ten mongrel dogs were used in this study. Diabetes was chemically induced in 7 dogs, and
3 dogs served as normal controls. For each diabetic dog, 5 million human bone marrow …

Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic
islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated …

Hypoxic injury of islets is a major obstacle for encapsulated islet transplantation into the
peritoneal cavity. To improve oxygen delivery to encapsulated islets, we integrated 20% of …

As a sensory micro-organ, pancreatic β-cells continually respond to nutritional signals and
neuroendocrine input from other glucoregulatory organs. This sensory ability is essential for …

Transient global ischemia induces selective hippocampal pyramidal neuronal death. Under
conditions of severe ischemic hypoxia, hypoxia-inducible factor-1α (HIF-1α) induces …

A bioartifical pancreas (BAP) remains a promising approach for treating insulin‐dependent
diabetes. Several obstacles to the clinical implementation of a BAP remain, including …