Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Tumor emergence and progression is complicated by the dual role of reactive oxygen
species (ROS). Low concentrations of ROS are essential for many intracellular metabolic …

Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH
oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress …

There is a common agreement on the important role of the gastrointestinal microbiota in the
etiology of cancer. Benign probiotic yeast strains are able to ameliorate intestinal microbiota …

Colorectal cancer (CRC) is the third most common type of cancer worldwide. Red beetroot
(Beta vulgaris) contains Betanin as its major betacyanin, possessing wide proapoptotic …

Adenovirus was first identified in the 1950s and since then this pathogenic group of viruses
has been explored and transformed into a genetic transfer vehicle. Modification or deletion …

For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need
for novel therapies and improvement of existing modalities. We propose that p53 gene …

The majority of advanced breast cancer patients develop distal metastasis, including lung
and bone metastasis. However, effective therapeutic strategies to prevent metastasis are still …

Gene therapy has been evaluated for the treatment of prostate cancer and includes the
application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that …