Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

The Western-style diet is characterized by its highly processed and refined foods and high
contents of sugars, salt, and fat and protein from red meat. It has been recognized as the …

Glucocorticoids have profound effects on brain development and adult CNS function. Excess
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …

Context: 11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes are now appreciated to
be important regulators of hormone action at a tissue level. 11β-HSD1 is widely expressed …

In the last decade significant progress has been made in the understanding of
mineralocorticoid receptor (MR) function and its implications for physiology and disease …

OBJECTIVE Glucocorticoid excess is characterized by increased adiposity, skeletal
myopathy, and insulin resistance, but the precise molecular mechanisms are unknown …

The metabolic abnormalities found associated with high blood glucocorticoid levels (eg rare
Cushing's syndrome) include insulin-resistance, visceral obesity, hypertension …

Chronically elevated glucocorticoid levels cause obesity, diabetes, heart disease, mood
disorders and memory impairments. 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) …