HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …

All cells, from prokaryotes to vertebrates, synthesize vast amounts of ribosomal RNA to
produce the several million new ribosomes per generation that are required to maintain the …

We describe the construction, evaluation and application of cDNA libraries from unfertilized
oocytes, and single 2-cell, 4-cell, 7-cell and blastocyst stage embryos. The corresponding …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

The rRNAs constitute the catalytic and structural components of the ribosome, the protein
synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA …

Methylation of cytosines within the sequence CpG is essential for mouse development1 and
has been linked to transcriptional suppression in vertebrate systems2. Methyl-CpG binding …

Like most eukaryotic rDNA promoters, the promoter for rDNA in Saccharomyces cerevisiae
consists of two elements: a core element, which is essential, and an upstream element …

RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA
polymerase I (Pol I) in Saccharomyces cerevisiae. We have cloned the gene, determined the …

Architectural Transcription Factors posed to isopycnal, eddy mixing led to spurious
upwelling from the abyss into the top kilometer of the ocean, inshore of the Gulf Stream, in …

Ribosomal RNA gene transcription by RNA polymerase I (Pol I) is the driving force behind
ribosome biogenesis, vital to cell growth and proliferation. The key activator of Pol I …