The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Pharmaceutical analysis refers to an area of analytical chemistry that deals with active
compounds either by themselves (drug substance) or when formulated with excipients (drug …

Native top-down mass spectrometry is a fast, robust biophysical technique that can provide
molecular-scale information on the interaction between proteins or peptides and ligands …

Poor selectivity between cancer cells and normal cells is one of the major limitations of
cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells …

Antibiotic resistance has become a primary concern in medicine because of the overuse and
misuse of classical pharmaceuticals. Recently, nonbiological complex drugs (NBCDs) have …

Recent developments of therapeutic agents based on transition metals have attracted a
great deal of attention. Metal drugs have advantages over other small molecule drugs, and it …

Octahedral platinum (IV) complexes such as trans, trans, trans-[Pt (N3) 2 (OH) 2 (pyridine)
2](1) are stable in the dark, but potently cytotoxic to a range of cancer cells when activated …

The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-
damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single …

Electron capture dissociation (ECD) is a tandem mass spectrometry (MS/MS) method that
utilizes the interaction of ions and electrons. Its unique ability to preserve labile bonds …

The ruthenium complex is considered a potential agent that could avoid the side-effects and
chemoresistance of platinum-based anti-cancer drugs, such as cisplatin, carboplatin or …