Abstract Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in
mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low …

Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating
infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and …

Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness.
Clinical disease occurs variably throughout the cornea from epithelium to endothelium and …

Pathogens usurp host pathways to generate a permissive environment for their propagation.
The current spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar
enzymatic activity towards HS chains but which simultaneously performs other non …

Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …

Antiviral activities of Zn2+ ions for viral pathogenesis process and inhibition by Zn2+ ions for
host cell-virus growth have been investigated. Zn2+ ions inhibit viral entry, local replication …

Heparanase has been viewed as a promising anti-cancer drug target for almost two
decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase …