Systems biology of cancer metastasis
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
[HTML][HTML] Artificial intelligence and early detection of pancreatic cancer: 2020 summative review
Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis
and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly …
and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly …
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data
Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …
of publicly available information about biological pathways including biochemical reactions …
Combine and conquer: challenges for targeted therapy combinations in early phase trials
JS Lopez, U Banerji - Nature reviews Clinical oncology, 2017 - nature.com
Our increasing understanding of cancer biology has led to the development of molecularly
targeted anticancer drugs. The full potential of these agents has not, however, been …
targeted anticancer drugs. The full potential of these agents has not, however, been …
A review of connectivity map and computational approaches in pharmacogenomics
Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …
CellBox: interpretable machine learning for perturbation biology with application to the design of cancer combination therapy
Systematic perturbation of cells followed by comprehensive measurements of molecular and
phenotypic responses provides informative data resources for constructing computational …
phenotypic responses provides informative data resources for constructing computational …
Control of cell state transitions
Understanding cell state transitions and purposefully controlling them is a longstanding
challenge in biology. Here we present cell state transition assessment and regulation …
challenge in biology. Here we present cell state transition assessment and regulation …
[HTML][HTML] Machine learning in the prediction of cancer therapy
Resistance to therapy remains a major cause of cancer treatment failures, resulting in many
cancer-related deaths. Resistance can occur at any time during the treatment, even at the …
cancer-related deaths. Resistance can occur at any time during the treatment, even at the …
New perspectives, opportunities, and challenges in exploring the human protein kinome
LJ Wilson, A Linley, DE Hammond, FE Hood… - Cancer research, 2018 - AACR
The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising
therapeutic effect on melanoma. The development of strategies to better kill melanoma cells …
therapeutic effect on melanoma. The development of strategies to better kill melanoma cells …