Vulval squamous cell carcinoma and its precursors

N Singh, CB Gilks - Histopathology, 2020 - Wiley Online Library
Vulval squamous cell carcinoma (VSCC) can arise through two distinct pathways [human
papillomavirus (HPV)‐associated and HPV‐independent], and these VSCC variants are …

[HTML][HTML] 2020 WHO classification of female genital tumors

AK Höhn, CE Brambs, GGR Hiller… - Geburtshilfe und …, 2021 - thieme-connect.com
In der WHO-Klassifikation 2020 steht die Unterscheidung von HPV-assoziierten und HPV-
unabhängigen Plattenepithelkarzinomen des unteren weiblichen Genitales im Vordergrund …

British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice

J Morrison, P Baldwin, L Buckley, L Cogswell… - European Journal of …, 2020 - Elsevier
The purpose of this guideline is to collate evidence and propose evidence-based guidelines
for the diagnosis and management of adult patients with vulva carcinoma treated in the UK …

Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status

B Tessier-Cloutier, KE Kortekaas, E Thompson… - Modern …, 2020 - nature.com
The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be
stratified into two prognostically relevant groups based on human papillomavirus (HPV) …

British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: An update on recommendations for practice 2023

J Morrison, P Baldwin, L Hanna, A Andreou… - European Journal of …, 2024 - Elsevier
Evidence was searched in the Cochrane Central Register of Controlled Trials (CENTRAL,
The Cochrane Library April 2022, Issue 4), MEDLINE and EMBASE up to April 2022, with …

The prognostic significance of HPV, p16, and p53 protein expression in vaginal cancer: A systematic review

CL Rasmussen, HK Bertoli, FL Sand… - Acta obstetricia et …, 2021 - Wiley Online Library
Introduction Human papillomavirus (HPV), p16, and p53 have been investigated as
prognostic markers in various HPV‐related cancers. Within the field of vaginal cancer …

Genomic signatures in HPV-associated tumors

SS Hussain, D Lundine, JE Leeman, DS Higginson - Viruses, 2021 - mdpi.com
Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA
synthesis in S phase, which is a requirement for viral replication. The human …

p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in …

L Woelber, K Prieske, C Eulenburg… - American Journal of …, 2021 - Elsevier
Background There are 2 known pathways for tumorigenesis of vulvar squamous cell
carcinoma—a human papillomavirus–dependent pathway characterized by p16 …

Molecular pathways in vulvar squamous cell carcinoma: implications for target therapeutic strategies

G Mantovani, SM Fragomeni, F Inzani, A Fagotti… - Journal of cancer …, 2020 - Springer
Background Additional prognostic factors and personalized therapeutic alternatives for
vulvar squamous cell carcinoma (VSCC), especially for advanced stages with poor …

Prognostic value of HPV-PCR, p16 and p53 immunohistochemical status on local recurrence rate and survival in patients with vulvar squamous cell carcinoma

AW Pouwer, NC Te Grootenhuis, F Hinten, GH de Bock… - Virchows Archiv, 2024 - Springer
The primary aim of this study was to assess the association between human papilloma virus
(HPV) and p53 expression and local recurrence (LR), disease specific survival (DSS), and …