Preclinical evidence has firmly established bidirectional interactions among the brain, the
gut, and the gut microbiome. Candidate signaling molecules and at least three …

Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

Emerging evidence indicates that gut microbiota is important in the regulation of brain
activity and cognitive functions. Microbes mediate communication among the metabolic …

The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …

In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …