Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

KA Kline, AL Lewis - Urinary tract infections: molecular …, 2017 - Wiley Online Library
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

D Lebeaux, A Chauhan, O Rendueles, C Beloin - Pathogens, 2013 - mdpi.com
The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …

Options and limitations in clinical investigation of bacterial biofilms

M Magana, C Sereti, A Ioannidis… - Clinical Microbiology …, 2018 - Am Soc Microbiol
Bacteria can form single-and multispecies biofilms exhibiting diverse features based upon
the microbial composition of their community and microenvironment. The study of bacterial …

“It takes a village”: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms

G Orazi, GA O'Toole - Journal of Bacteriology, 2019 - Am Soc Microbiol
Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these
infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to …

Infection in an aging population

KA Kline, DME Bowdish - Current opinion in microbiology, 2016 - Elsevier
Highlights•One third of deaths in adults in the elderly are due to infectious disease.•Changes
in the aging immune response increase the risk of infection in the elderly.•Respiratory …

Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lower urinary tract symptoms

R Khasriya, S Sathiananthamoorthy… - Journal of clinical …, 2013 - Am Soc Microbiol
Chronic lower urinary tract symptoms (LUTS), such as urgency and incontinence, are
common, especially among the elderly, but their etiology is often obscure. Recent studies of …

Mechanisms of synergy in polymicrobial infections

JL Murray, JL Connell, A Stacy, KH Turner… - Journal of …, 2014 - Springer
Communities of microbes can live almost anywhere and contain many different species.
Interactions between members of these communities often determine the state of the habitat …

[HTML][HTML] Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models

AL Lewis, NM Gilbert - GMS infectious diseases, 2020 - ncbi.nlm.nih.gov
Mounting evidence indicates that the vagina can harbor uropathogenic bacteria. Here, we
consider three roles played by the vagina and its bacterial inhabitants in urinary tract …

Enzymatic modifications of exopolysaccharides enhance bacterial persistence

GB Whitfield, LS Marmont, PL Howell - Frontiers in microbiology, 2015 - frontiersin.org
Biofilms are surface-attached communities of bacterial cells embedded in a self-produced
matrix that are found ubiquitously in nature. The biofilm matrix is composed of various …

Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease

NM Gilbert, VP O'Brien, AL Lewis - PLoS pathogens, 2017 - journals.plos.org
Pathogens often inhabit the body asymptomatically, emerging to cause disease in response
to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are …