[HTML][HTML] REST, RCOR1 and RCOR2 expression is reduced in osteoarthritic chondrocytes and contributes to increasing MMP13 and ADAMTS5 expression through …

JGB Primrose, L Jain, M Alhilali, SM Bolam, AP Monk… - Cellular …, 2023 - Elsevier
Expression of key transcriptional regulators is altered in chondrocytes in osteoarthritis (OA).
This contributes to an increase in production of cartilage-catabolizing enzymes such as …

[HTML][HTML] Phenotype and energy metabolism differ between osteoarthritic chondrocytes from male compared to female patients: Implications for sexual dimorphism in …

L Jain, CA Jardim, R Yulo, SM Bolam, AP Monk… - Osteoarthritis and …, 2023 - Elsevier
summary Objectives The prevalence and severity of knee osteoarthritis (OA) are greater in
females than males. The purpose of this study was to determine whether there is an …

Elevated glucose promotes MMP13 and ADAMTS5 production by osteoarthritic chondrocytes under oxygenated but not hypoxic conditions

L Jain, SM Bolam, P Monk, JT Munro… - Journal of Cellular …, 2024 - Wiley Online Library
Type 2 diabetes is linked with increased incidence and severity of osteoarthritis. The
purpose of this study was to determine the effect of extracellular glucose within the normal …

针刀调控软骨细胞自噬维持骨关节炎软骨细胞的稳态

贾小飞, 冉丽, 马小双, 黑晓燕, 刘佳妮, 杨楠, 马海滨… - 中国组织工程研究, 2024 - cjter.com
针刀调控软骨细胞自噬维持骨关节炎软骨细胞的稳态 Page 1 5452|中国组织工程研究|第28卷|第
34期|2024年12月 中国组织工程研究 Chinese Journal of Tissue Engineering Research www.CJTER.com …

Regulation of chondrocyte autophagy by acupotomy to promote chondrocyte homeostasis in osteoarthritis

X Jia, L Ran, X Ma, X Hei, J Liu, N Yang, H Ma… - Chinese Journal of …, 2024 - cjter.com
BACKGROUND: Acupotomy is an effective method for the clinical treatment of osteoarthritis,
with affirmed clinical outcomes, but the specific mechanisms remain unclear OBJECTIVE: To …