Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Mitochondrial dysfunction underlies many prevalent diseases including heart disease
arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy …

Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …

N‐Methyl‐D‐aspartate receptors (NMDARs) have two opposing roles in the brain. On the
one hand, NMDARs control critical events in the formation and development of synaptic …

Platelets, the small, anucleate blood cells that originate from megakaryocytes in the bone
marrow, are typically associated with coagulation. However, it is now apparent that platelets …

It is now apparent that platelet function is more diverse than originally thought, shifting the
view of platelets from blood cells involved in hemostasis and wound healing to major …

Inflammation is increasingly implicated in neurodegenerative disease pathology. As no
acquired pathogen appears to drive this inflammation, the question of what does remains …

Aim: To investigate mitochondrial DNA (mtDNA) copy number and D-loop region
methylation in carriers of SOD1, TARDBP, FUS and C9orf72 mutations. Methods …