Introduction Several experimental models have been designed to promote the development
of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely …

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

Abstract The European Joint Program “HBM4EU” is a joint effort of 30 countries and the
European Environment Agency, co-funded under the European Commission's Horizon 2020 …

Aspartame has been studied extensively and evaluated for its safety in foods and beverages
yet concerns for its potential carcinogenicity have persisted, driven primarily by animal …

Objectives This systematic review aimed to compare the cytotoxicity of root canal filling
materials (RCFMs) assessed using tetrazolium salt‐based tests (TSBT), including the 3‐(4, 5 …

The workshop titled “Application of evidence-based methods to construct mechanism-driven
chemical assessment frameworks” was co-organized by the Evidence-based Toxicology …

The toxic equivalency factors (TEFs) approach for dioxin-like chemicals (DLCs) is currently
based on a qualitative assessment of a heterogeneous data set of relative estimates of …

Efficient and successful integration of data generated from non-animal test methods must
rely on reliable and relevant data. It is important therefore to develop tools and criteria that …

Irrigant solutions are used to promote dentin-growth factors (GF) release for regenerative
endodontics. This review aimed to evaluate the reports comparing the release of GFs using …

Microplastics have been documented in drinking water, but their effects on human health
from ingestion, or the concentrations at which those effects begin to manifest, are not …