Nanotools for sepsis diagnosis and treatment

L Papafilippou, A Claxton, P Dark… - Advanced …, 2021 - Wiley Online Library
Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Phage display in the quest for new selective recognition elements for biosensors

R Peltomaa, E Benito-Peña, R Barderas… - Acs Omega, 2019 - ACS Publications
Phages are bacterial viruses that have gained a significant role in biotechnology owing to
their widely studied biology and many advantageous characteristics. Perhaps the best …

Quantitative and specific detection of exosomal miRNAs for accurate diagnosis of breast cancer using a surface‐enhanced Raman scattering sensor based on …

JU Lee, WH Kim, HS Lee, KH Park, SJ Sim - Small, 2019 - Wiley Online Library
MicroRNAs in exosomes (exosomal miRNAs) have attracted increased attention as cancer
biomarkers for early diagnosis and prognosis owing to their stability in body fluids. Since …

Rapid and digital detection of inflammatory biomarkers enabled by a novel portable nanoplasmonic imager

A Belushkin, F Yesilkoy, JJ González‐López… - Small, 2020 - Wiley Online Library
New point‐of‐care diagnostic devices are urgently needed for rapid and accurate diagnosis,
particularly in the management of life‐threatening infections and sepsis, where immediate …

Aptamer-based novel Ag-coated magnetic recognition and SERS nanotags with interior nanogap biosensor for ultrasensitive detection of protein biomarker

Z Hu, X Zhou, J Duan, X Wu, J Wu, P Zhang… - Sensors and Actuators B …, 2021 - Elsevier
The design of a rapid, simple, and ultrasensitive detection platform of protein biomarkers has
become an urgent need in early diagnosis and treatment. Surface-enhanced Raman …

M13 phage-based nanoprobe for SERS detection and inactivation of Staphylococcus aureus

XY Wang, JY Yang, YT Wang, HC Zhang, ML Chen… - Talanta, 2021 - Elsevier
Rapid and sensitive diagnosis of bacterial infections at early stage is of great significance for
food safety monitoring as well as clinical treatment. Herein, we construct a surface …

Highly sensitive surface-enhanced Raman scattering-based immunosensor incorporating half antibody-fragment for quantitative detection of Alzheimer's disease …

SJ Yang, JU Lee, MJ Jeon, SJ Sim - Analytica Chimica Acta, 2022 - Elsevier
Blood-based detection of Alzheimer's disease (AD) biomarker has become a prominent
method for diagnosis of AD which can replace the complex and invasive cerebrospinal fluid …

Phage display based biosensing: Recent advances and challenges

M Wang, S Pang, H Zhang, Z Yang, A Liu - TrAC Trends in Analytical …, 2024 - Elsevier
Phage display enables to screen probes such as peptide, antibody and nanobody with high
specificity and affinity to the target, providing excellent probes for various analytical or …

Protein corona fingerprinting to differentiate sepsis from non-infectious systemic inflammation

L Papafilippou, A Claxton, P Dark, K Kostarelos… - Nanoscale, 2020 - pubs.rsc.org
Rapid and accurate diagnosis of sepsis remains clinically challenging. The lack of specific
biomarkers that can differentiate sepsis from non-infectious systemic inflammatory diseases …

Lateral flow immunoassay based on surface-enhanced Raman scattering using pH-induced phage-templated hierarchical plasmonic assembly for point-of-care …

MJ Jeon, SK Kim, SH Hwang, JU Lee, SJ Sim - Biosensors and …, 2024 - Elsevier
The outbreak of emerging infectious diseases gave rise to the demand for reliable point-of-
care testing methods to diagnose and manage those diseases in early onset. However, the …