Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
Infectious RNA: human immunodeficiency virus (HIV) biology, therapeutic intervention, and the quest for a vaccine
Y van Heuvel, S Schatz, JF Rosengarten, J Stitz - Toxins, 2022 - mdpi.com
Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …
host cell factors to enable virus replication. The viral genomic RNA of the human …
HIV-1: to splice or not to splice, that is the question
A Emery, R Swanstrom - Viruses, 2021 - mdpi.com
The transcription of the HIV-1 provirus results in only one type of transcript—full length
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
Nano-DMS-MaP allows isoform-specific RNA structure determination
Genome-wide measurements of RNA structure can be obtained using reagents that react
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble
T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
Kinetic resolution of the atomic 3D structures formed by ground and excited conformational states in an RNA dynamic ensemble
Knowing the 3D structures formed by the various conformations populating the RNA free-
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR
Appended to the 5′ end of nascent RNA polymerase II transcripts is 7-methyl guanosine
(m7G-cap) that engages nuclear cap-binding complex (CBC) to facilitate messenger RNA …
(m7G-cap) that engages nuclear cap-binding complex (CBC) to facilitate messenger RNA …
5′-Cap sequestration is an essential determinant of HIV-1 genome packaging
P Ding, S Kharytonchyk, N Kuo… - Proceedings of the …, 2021 - National Acad Sciences
HIV-1 selectively packages two copies of its 5′-capped RNA genome (gRNA) during virus
assembly, a process mediated by the nucleocapsid (NC) domain of the viral Gag polyprotein …
assembly, a process mediated by the nucleocapsid (NC) domain of the viral Gag polyprotein …
Short-and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation
HIV-1 transcript function is controlled in part by twinned transcriptional start site usage,
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …