Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

Honey bees can be found all around the world and fulfill key pollination roles within their
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …

Abstract Ca2+-activated K+ (KCa) channels of small (SK) and intermediate (IK) conductance
are present in a wide range of excitable and non-excitable cells. On activation by low …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Introduction: PPIs are involved in every disease and specific modulation of these PPIs with
small molecules would significantly improve our prospects of developing therapeutic agents …

Four families of potassium channels with different structures, functional characteristics and
pharmacological sensitivity, are distinguished in neurons: voltage-gated (Kv), calcium …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …