Excessive reactive oxygen species Revised abstract, especially superoxide anion (O2•−),
play important roles in the pathogenesis of many cardiovascular diseases, including …

Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …

Angiogenesis is essential for tumor growth, metastasis, arteriosclerosis as well as embryonic
development and wound healing. Its process is dependent on cell proliferation, migration …

Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful …

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master
regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively …

Although platinum-based drugs such as cisplatin are powerful anticancer agents, they have
undesirable side effects and are effective against only a few kinds of cancers. There is …

Although there have been a multitude of studies, the mechanisms of angiogenesis remain
incompletely understood. Increasing evidence suggests that cellular redox homeostasis is …

Islet cell transplantation has therapeutic potential to treat type 1 diabetes, which is
characterized by autoimmune destruction of insulin-producing pancreatic islet β cells. It …