Obesity, fat mass and immune system: role for leptin

V Francisco, J Pino, V Campos-Cabaleiro… - Frontiers in …, 2018 - frontiersin.org
Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Obesity in autoimmune diseases: not a passive bystander

M Versini, PY Jeandel, E Rosenthal, Y Shoenfeld - Autoimmunity reviews, 2014 - Elsevier
In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and …

JM Gwinnutt, M Wieczorek, G Cavalli, A Balanescu… - RMD open, 2022 - rmdopen.bmj.com
Background A European League Against Rheumatism (EULAR) taskforce was convened to
develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal …

Impact of obesity on remission and disease activity in rheumatoid arthritis: a systematic review and meta‐analysis

Y Liu, GS Hazlewood, GG Kaplan… - Arthritis care & …, 2017 - Wiley Online Library
Objective To summarize the relationship between obesity and remission in rheumatoid
arthritis (RA); secondary objectives were to summarize other measures of treatment …

The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis

LR Baghdadi, RJ Woodman, EM Shanahan… - PloS one, 2015 - journals.plos.org
Background Rheumatoid arthritis (RA) is known to increase the risk of cardiovascular (CV)
disease. However, the individual impact of traditional CV risk factors in RA is unknown …

State of the science: chronic periodontitis and systemic health

J Otomo-Corgel, JJ Pucher, MP Rethman… - Journal of Evidence …, 2012 - Elsevier
CONTEXT: Inflammatory periodontal diseases exhibit an association with multiple systemic
conditions. Currently, there is a lack of consensus among experts on the nature of these …

Difficult-to-treat rheumatoid arthritis: an area of unmet clinical need

MJH de Hair, JWG Jacobs, JLM Schoneveld… - …, 2018 - academic.oup.com
Increased effectiveness of pharmacological treatments in early RA has led many to believe
that difficult-to-treat, established RA is a condition of the past. However, there are still plenty …

A global perspective on the crosstalk between saturated fatty acids and Toll-like receptor 4 in the etiology of inflammation and insulin resistance

B Li, JCK Leung, LYY Chan, WH Yiu… - Progress in lipid research, 2020 - Elsevier
Obesity is featured by chronic systemic low-grade inflammation that eventually contributes to
the development of insulin resistance. Toll-like receptor 4 (TLR4) is an important mediator …

Autoantibody production in obesity: is there evidence for a link between obesity and autoimmunity?

C Tsigalou, N Vallianou, M Dalamaga - Current Obesity Reports, 2020 - Springer
Abstract Purpose of Review During the last decades, obesity and autoimmune disorders
have shown a parallel significant rise in industrialized countries. This review aims at …

The challenging interplay between rheumatoid arthritis, ageing and comorbidities

M van Onna, A Boonen - BMC musculoskeletal disorders, 2016 - Springer
Background The incidence of rheumatoid arthritis (RA) is expected to increase over the next
10 years in the European Union because of the increasing proportion of elderly people. As …