The capture of CO2 by carboxylases is key to sustainable biocatalysis and a carbon-neutral
bio-economy, yet currently limited to few naturally existing enzymes. Here, we developed …

Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a
variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a …

Photorespiration recycles ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rubisco)
oxygenation product, 2-phosphoglycolate, back into the Calvin Cycle. Natural …

The biosynthesis of various useful chemicals from simple substrates using industrial
microorganisms is becoming increasingly crucial to address the challenge of dwindling non …

Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive
target for drug discovery against diabetes, cancer and other diseases,,,,,. Saccharomyces …

Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during
changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 …

Abstract Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid
biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are …

Abstract Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive
targets for drug discovery. Eukaryotic acetyl-CoA carboxylases are 250 kDa single-chain …

Data mining methods based on machine learning play an increasingly important role in drug
design and discovery. In the current work, eight machine learning methods including …

The selective incorporation of new-to-nature extender units into polyketide synthesis is a
highly effective way to engineer their carbon scaffolds. Currently, most atypical extender …