Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to
cardiovascular disease accounting for the high mortality in the United States. For developing …

Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the
efficiency of drug development and realize personalized medicine by simulating in vivo …

The ability to customize medical choices according to an individual's genetic makeup and
biomarker patterns marks a significant advancement toward overall improved healthcare for …

The tissue-engineered blood vessel (TEBV) has been developed and used in
cardiovascular disease modeling, preclinical drug screening, and for replacement of native …

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, fatal genetic disease that
accelerates atherosclerosis. With a limited pool of HGPS patients, clinical trials face unique …

Organ-on-a-chip (OOC) is a new type of biochip technology. Various types of OOC systems
have been developed rapidly in the past decade and found important applications in drug …

Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of
death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD …

Bone tissue engineering (BTE) uses engineering principles to repair large bone defects,
which requires effective mass transport ability of scaffolds to support cellular activities during …

Blood vessels are subjected to complex biomechanical loads, primarily from pressure-driven
blood flow. Abnormal loading associated with vascular grafts, arising from altered …