The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible.
Here, we present CEL-Seq2, a modified version of our CEL-Seq method, with threefold …

To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell
phenotype, we characterized those host phagocytes that controlled or supported bacterial …

The transcriptome of single cells can reveal important information about cellular states and
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …

A dichotomous choice for metazoan cells is between proliferation and differentiation.
Measuring tRNA pools in various cell types, we found two distinct subsets, one that is …

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the …

One promising approach for in vivo studies of cell proliferation is the FUCCI system
(fluorescent ubiquitination-based cell cycle indicator). Here, we report the development of a …

Hepatocytes have a critical role in metabolism, but their study is limited by the inability to
expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic …

Elucidation of cellular and gene regulatory networks (GRNs) governing organ development
will accelerate progress toward tissue replacement. Here, we have compiled reference …