Liver regeneration: biological and pathological mechanisms and implications
GK Michalopoulos, B Bhushan - Nature reviews Gastroenterology & …, 2021 - nature.com
The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …
Liver regeneration
GK Michalopoulos - The liver: biology and pathobiology, 2020 - Wiley Online Library
Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
T Hashimshony, N Senderovich, G Avital… - Genome biology, 2016 - Springer
Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible.
Here, we present CEL-Seq2, a modified version of our CEL-Seq method, with threefold …
Here, we present CEL-Seq2, a modified version of our CEL-Seq method, with threefold …
[HTML][HTML] Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny
L Huang, EV Nazarova, S Tan, Y Liu… - The Journal of …, 2018 - ncbi.nlm.nih.gov
To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell
phenotype, we characterized those host phagocytes that controlled or supported bacterial …
phenotype, we characterized those host phagocytes that controlled or supported bacterial …
[HTML][HTML] Computational assignment of cell-cycle stage from single-cell transcriptome data
The transcriptome of single cells can reveal important information about cellular states and
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …
A dual program for translation regulation in cellular proliferation and differentiation
A dichotomous choice for metazoan cells is between proliferation and differentiation.
Measuring tRNA pools in various cell types, we found two distinct subsets, one that is …
Measuring tRNA pools in various cell types, we found two distinct subsets, one that is …
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
L Planas-Paz, V Orsini, L Boulter, D Calabrese… - Nature cell …, 2016 - nature.com
LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the …
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the …
Fly-FUCCI: A versatile tool for studying cell proliferation in complex tissues
N Zielke, J Korzelius, M van Straaten, K Bender… - Cell reports, 2014 - cell.com
One promising approach for in vivo studies of cell proliferation is the FUCCI system
(fluorescent ubiquitination-based cell cycle indicator). Here, we report the development of a …
(fluorescent ubiquitination-based cell cycle indicator). Here, we report the development of a …
Long-term culture and expansion of primary human hepatocytes
Hepatocytes have a critical role in metabolism, but their study is limited by the inability to
expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic …
expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic …
Gene regulatory networks governing pancreas development
HE Arda, CM Benitez, SK Kim - Developmental cell, 2013 - cell.com
Elucidation of cellular and gene regulatory networks (GRNs) governing organ development
will accelerate progress toward tissue replacement. Here, we have compiled reference …
will accelerate progress toward tissue replacement. Here, we have compiled reference …