Microbial adaptation to enhance stress tolerance
Microbial cell factories have been widely used in the production of various chemicals.
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …
Carbon-negative synthetic biology: challenges and emerging trends of cyanobacterial technology
Global warming and climate instability have spurred interest in using renewable carbon
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol
J Gao, Y Li, W Yu, YJ Zhou - Nature Metabolism, 2022 - nature.com
Methanol is an ideal feedstock for biomanufacturing that can be beneficial for global carbon
neutrality; however, the toxicity of methanol limits the efficiency of methanol metabolism …
neutrality; however, the toxicity of methanol limits the efficiency of methanol metabolism …
De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts
Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph
Methanol, an organic one-carbon (C1) compound, represents an attractive alternative
carbon source for microbial fermentation. Despite considerable advancements in methanol …
carbon source for microbial fermentation. Despite considerable advancements in methanol …
Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery
S Chen, Z Xu, B Ding, Y Zhang, S Liu, C Cai, M Li… - Science …, 2023 - science.org
The isomerization of xylose to xylulose is considered the most promising approach to initiate
xylose bioconversion. Here, phylogeny-guided big data mining, rational modification, and …
xylose bioconversion. Here, phylogeny-guided big data mining, rational modification, and …
Mining natural products for advanced biofuels and sustainable bioproducts
Highlights•Natural products offer a broad chemical catalog for bio-based product
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …
Clostridium as microbial cell factory to enable the sustainable utilization of three generations of feedstocks
Z Yang, DD Leero, C Yin, L Yang, L Zhu, Z Zhu… - Bioresource …, 2022 - Elsevier
The sustainable production of chemicals and biofuels from non-fossil carbon sources is
considered key to reducing greenhouse gas (GHG) emissions. Clostridium sp. can convert …
considered key to reducing greenhouse gas (GHG) emissions. Clostridium sp. can convert …
[HTML][HTML] Engineering of Saccharomyces cerevisiae for co-fermentation of glucose and xylose: current state and perspectives
Y Qiu, M Wu, H Bao, W Liu, Y Shen - Engineering Microbiology, 2023 - Elsevier
The use of non-food lignocellulosic biomass to produce ethanol fits into the strategy of a
global circular economy with low dependence on fossil energy resources. Xylose is the …
global circular economy with low dependence on fossil energy resources. Xylose is the …
Self-assembly systems to troubleshoot metabolic engineering challenges
Z Chen, T Wu, S Yu, M Li, X Fan, YX Huo - Trends in Biotechnology, 2024 - cell.com
Enzyme self-assembly is a technology in which enzyme units can aggregate into ordered
macromolecules, assisted by scaffolds. In metabolic engineering, self-assembly strategies …
macromolecules, assisted by scaffolds. In metabolic engineering, self-assembly strategies …