Microbial adaptation to enhance stress tolerance

YS Tan, RK Zhang, ZH Liu, BZ Li, YJ Yuan - Frontiers in Microbiology, 2022 - frontiersin.org
Microbial cell factories have been widely used in the production of various chemicals.
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …

Carbon-negative synthetic biology: challenges and emerging trends of cyanobacterial technology

C Tan, P Xu, F Tao - Trends in biotechnology, 2022 - cell.com
Global warming and climate instability have spurred interest in using renewable carbon
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …

Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol

J Gao, Y Li, W Yu, YJ Zhou - Nature Metabolism, 2022 - nature.com
Methanol is an ideal feedstock for biomanufacturing that can be beneficial for global carbon
neutrality; however, the toxicity of methanol limits the efficiency of methanol metabolism …

De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

C Zhan, X Li, G Lan, EEK Baidoo, Y Yang, Y Liu… - Nature Catalysis, 2023 - nature.com
Methanol, an organic one-carbon (C1) compound, represents an attractive alternative
carbon source for microbial fermentation. Despite considerable advancements in methanol …

Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery

S Chen, Z Xu, B Ding, Y Zhang, S Liu, C Cai, M Li… - Science …, 2023 - science.org
The isomerization of xylose to xylulose is considered the most promising approach to initiate
xylose bioconversion. Here, phylogeny-guided big data mining, rational modification, and …

Mining natural products for advanced biofuels and sustainable bioproducts

X Li, AE Gadar-Lopez, L Chen, S Jayachandran… - Current Opinion in …, 2023 - Elsevier
Highlights•Natural products offer a broad chemical catalog for bio-based product
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …

Clostridium as microbial cell factory to enable the sustainable utilization of three generations of feedstocks

Z Yang, DD Leero, C Yin, L Yang, L Zhu, Z Zhu… - Bioresource …, 2022 - Elsevier
The sustainable production of chemicals and biofuels from non-fossil carbon sources is
considered key to reducing greenhouse gas (GHG) emissions. Clostridium sp. can convert …

[HTML][HTML] Engineering of Saccharomyces cerevisiae for co-fermentation of glucose and xylose: current state and perspectives

Y Qiu, M Wu, H Bao, W Liu, Y Shen - Engineering Microbiology, 2023 - Elsevier
The use of non-food lignocellulosic biomass to produce ethanol fits into the strategy of a
global circular economy with low dependence on fossil energy resources. Xylose is the …

Self-assembly systems to troubleshoot metabolic engineering challenges

Z Chen, T Wu, S Yu, M Li, X Fan, YX Huo - Trends in Biotechnology, 2024 - cell.com
Enzyme self-assembly is a technology in which enzyme units can aggregate into ordered
macromolecules, assisted by scaffolds. In metabolic engineering, self-assembly strategies …