The prevalence of opioid use disorder and overdose continues to harm the US population
and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs …

Background Fentanyl is commonly laced with xylazine. People who use this combination
report heightened effects, but it also increases death risk. Although no medication has been …

Over 50 million Americans endure chronic pain where many do not receive adequate
treatment and self-medicate to manage their pain by taking substances like opioids and …

Opioid use disorder occurs alongside impaired risk-related decision-making, but the
underlying neural correlates are unclear. We developed a novel approach-avoidance …

Background: The rise in overdose deaths from synthetic opioids, especially fentanyl,
necessitates the development of preclinical models to study fentanyl use disorder (FUD) …

Opioids such as morphine are the first choice in acute and chronic pain treatment. However,
they lead to addiction. Several studies have searched (i) to find a molecule that can replace …

Chronic neuropathic pain affects~ 6.9-10% of the American population. Previous research
suggested that chronic pain conditions may increase the susceptibility to developing an …