Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology
C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …
highly coordinated developmental events, such as cell proliferation, migration, and …
Retinal waves coordinate patterned activity throughout the developing visual system
The morphological and functional development of the vertebrate nervous system is initially
governed by genetic factors and subsequently refined by neuronal activity. However …
governed by genetic factors and subsequently refined by neuronal activity. However …
[HTML][HTML] Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
Disorders of vascular structure and function play a central role in a wide variety of CNS
diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause …
diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause …
The nuclear receptors COUP-TF: a long-lasting experience in forebrain assembly
C Alfano, E Magrinelli, K Harb, M Studer - Cellular and molecular life …, 2014 - Springer
Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are nuclear
receptors belonging to the superfamily of the steroid/thyroid hormone receptors. Members of …
receptors belonging to the superfamily of the steroid/thyroid hormone receptors. Members of …
Complementary domains of retinoic acid production and degradation in the early chick embryo
EC Swindell, C Thaller, S Sockanathan… - Developmental …, 1999 - Elsevier
Excess retinoids as well as retinoid deprivation cause abnormal development, suggesting
that retinoid homeostasis is critical for proper morphogenesis. RALDH-2 and CYP26, two …
that retinoid homeostasis is critical for proper morphogenesis. RALDH-2 and CYP26, two …
Visual map development depends on the temporal pattern of binocular activity in mice
Binocular competition is thought to drive eye-specific segregation in the developing visual
system, potentially through Hebbian synaptic learning rules that are sensitive to correlations …
system, potentially through Hebbian synaptic learning rules that are sensitive to correlations …
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis
Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic
metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is …
metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is …
Visual cortex gains independence from peripheral drive before eye opening
Visual spatial perception in the mammalian brain occurs through two parallel pathways: one
reaches the primary visual cortex (V1) through the thalamus and another the superior …
reaches the primary visual cortex (V1) through the thalamus and another the superior …
Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice
SJ Garnai, ML Brinkmeier, B Emery, TS Aleman… - PLoS …, 2019 - journals.plos.org
Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …
COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
Transcriptional networks, which are initiated by secreted proteins, cooperate with each other
to orchestrate eye development. The establishment of dorsal/ventral polarity, especially …
to orchestrate eye development. The establishment of dorsal/ventral polarity, especially …