Progress on green crosslinking of polysaccharide hydrogels for drug delivery and tissue engineering applications
Natural polysaccharides are being studied for their biocompatibility, biodegradability, low
toxicity, and low cost in the fabrication of various hydrogel devices. However, due to their …
toxicity, and low cost in the fabrication of various hydrogel devices. However, due to their …
The versatility of squaramides: From supramolecular chemistry to chemical biology
LA Marchetti, LK Kumawat, N Mao, JC Stephens… - Chem, 2019 - cell.com
This review covers recent advances in the use of the squaramide moiety in chemical
research. We focus on the varied applications of squaramides under the broad headings of …
research. We focus on the varied applications of squaramides under the broad headings of …
Comparative study of gelatin hydrogels modified by various cross-linking agents
J Skopinska-Wisniewska, M Tuszynska… - Materials, 2021 - mdpi.com
Gelatin is a natural biopolymer derived from collagen. Due to its many advantages, such as
swelling capacity, biodegradability, biocompatibility, and commercial availability, gelatin is …
swelling capacity, biodegradability, biocompatibility, and commercial availability, gelatin is …
Quinoline-based antimalarial hybrid compounds
S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2015 - Elsevier
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
High‐Affinity Anion Binding by Steroidal Squaramide Receptors
SJ Edwards, H Valkenier, N Busschaert… - Angewandte …, 2015 - Wiley Online Library
Exceptionally powerful anion receptors have been constructed by placing squaramide
groups in axial positions on a steroidal framework. The steroid preorganizes the squaramide …
groups in axial positions on a steroidal framework. The steroid preorganizes the squaramide …
Squaramides as bioisosteres in contemporary drug design
KA Agnew-Francis, CM Williams - Chemical Reviews, 2020 - ACS Publications
Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …
Squaric acid analogues in medicinal chemistry
J Chasák, V Šlachtová, M Urban, L Brulíková - European Journal of …, 2021 - Elsevier
In this review, we summarize the published data on squaric acid analogues with a special
focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an …
focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an …
Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity
MP Carrasco, AS Newton, L Gonçalves, A Góis… - European journal of …, 2014 - Elsevier
A library comprising 44 diversely substituted aurones derivatives was synthesized by
straightforward aldol condensation reactions of benzofuranones and the appropriately …
straightforward aldol condensation reactions of benzofuranones and the appropriately …
Synthesis and Biological Evaluation of N,N′-Squaramides with High in Vivo Efficacy and Low Toxicity: Toward a Low-Cost Drug against Chagas Disease
Access to basic drugs is a major issue in developing countries. Chagas disease caused by
Trypanosoma cruzi is a paradigmatic example of a chronic disease without an effective …
Trypanosoma cruzi is a paradigmatic example of a chronic disease without an effective …
Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges
KK Roy - International Journal of Antimicrobial Agents, 2017 - Elsevier
Malaria is an infectious disease causing vast mortality and morbidity worldwide. Although
antimalarial drugs are effective in several parts of the world, there is a serious threat to …
antimalarial drugs are effective in several parts of the world, there is a serious threat to …