Polo-like kinase 1 (PLK1) signaling in cancer and beyond
S Iliaki, R Beyaert, IS Afonina - Biochemical pharmacology, 2021 - Elsevier
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
Post-translational modification of factors involved in homologous recombination
B Argunhan, H Iwasaki, H Tsubouchi - Dna Repair, 2021 - Elsevier
DNA is the molecule that stores the chemical instructions necessary for life and its stability is
therefore of the utmost importance. Despite this, DNA is damaged by both exogenous and …
therefore of the utmost importance. Despite this, DNA is damaged by both exogenous and …
Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila
V Emond-Fraser, M Larouche, P Kubiniok… - Open …, 2023 - royalsocietypublishing.org
Mitotic exit requires the dephosphorylation of many proteins whose phosphorylation was
needed for mitosis. Protein phosphatase 2A with its B55 regulatory subunit (PP2A-B55) …
needed for mitosis. Protein phosphatase 2A with its B55 regulatory subunit (PP2A-B55) …
Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression
M Larouche, D Kachaner, P Wang, K Normandin… - Journal of Cell …, 2021 - rupress.org
Mitotic entry involves inhibition of protein phosphatase 2A bound to its B55/Tws regulatory
subunit (PP2A-B55/Tws), which dephosphorylates substrates of mitotic kinases. This …
subunit (PP2A-B55/Tws), which dephosphorylates substrates of mitotic kinases. This …
Discovery and characterization of a novel MASTL inhibitor MKI-2 targeting MASTL-PP2A in breast cancer cells and oocytes
M Kang, C Kim, J Leem, Y Kim, Y Kwon, YN Yoon… - Pharmaceuticals, 2021 - mdpi.com
Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target
for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor …
for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor …
IL-22 regulates MASTL expression in intestinal epithelial cells
Microtubule-associated serine-threonine kinase-like (MASTL) has recently been identified
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …
Targeted inhibition of MASTL kinase activity induces apoptosis in breast cancer
Microtubule-associated serine/threonine kinase-like (MASTL)(or Greatwall kinase (GWL)) is
an important cell cycle regulating kinase that regulates the G2-M transition. Uncontrolled …
an important cell cycle regulating kinase that regulates the G2-M transition. Uncontrolled …
[HTML][HTML] Hepatotoxicity of Silver Nanoparticles: Benchmark Concentration Modeling of an In Vitro Transcriptomics Study in Human iPSC-derived Hepatocytes
X Gao, WE Johnson, MR Yourick, K Campasino… - Regulatory Toxicology …, 2024 - Elsevier
Despite two decades of research on silver nanoparticle (AgNP) toxicity, a safe threshold for
exposure has not yet been established, albeit being critically needed for risk assessment …
exposure has not yet been established, albeit being critically needed for risk assessment …
SILAC kinase screen identifies potential MASTL substrates
Microtubule-associated serine/threonine kinase-like (MASTL) has emerged as a critical
regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp …
regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp …
Genetic complementation screening and molecular docking give new insight on phosphorylation-dependent Mastl kinase activation
Mastl is a mitotic kinase that is essential for error-free chromosome segregation. It is an
atypical member of AGC kinase family, possessing a unique non-conserved middle region …
atypical member of AGC kinase family, possessing a unique non-conserved middle region …