Breast cancer and prostate cancer are the two most common invasive cancers in women
and men, respectively. Although these cancers arise in organs that are different in terms of …

The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …

Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases,
such as the PI3K (phosphatidylinositol 3-kinase)–Akt pathway, the Ras–MAPK (mitogen …

Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …

Androgens control male sexual development and maintenance of the adult male phenotype.
They have very divergent effects on their target organs like the reproductive organs, muscle …

Aliment Pharmacol Ther 2011; 33: 801–814 Summary Background Polycystic ovary
syndrome (PCOS) is a common disorder for women of child‐bearing age and is associated …

Background: Epigenetic alterations are common in prostate cancer, yet how these
modifications contribute to carcinogenesis is poorly understood. We investigated whether …

The molecular mechanisms underlying diet-induced obesity are complex and remain
unclear. The activation of the aryl hydrocarbon receptor (AhR), a xenobiotic sensor, by …

The region between the DNA-binding domain and the ligand-binding domain of nuclear
receptors is termed the hinge region. Although this flexible linker is poorly conserved …

The importance of androgen receptor (AR) signaling is increasingly being recognized in
breast cancer, which has elicited clinical trials aimed at assessing the efficacy of androgen …