Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin–
melanocortin pathway in controlling energy balance, appetite and body weight. The majority …

Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …

Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

In addition to effects on appetite and metabolism, leptin influences many neuroendocrine
and physiological systems, including the sympathetic nervous system. Building on my Carl …