Substantial developments have occurred in the past 5–10 years in clinical translational
research of thyroid cancer. Diagnostic molecular markers, such as RET-PTC, RAS, and …

Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of
lymph node involvement is a key prognostic factor for the disease. Whereas the significance …

Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …

Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells
and predicts poor clinical prognosis. Lymphatic vessels generally arise within the …

Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth
factor‐C (VEGF‐C) is a recently described lymphangiogenic factor. Increased expression of …

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in …

Purpose There is no effective therapy for patients with distant metastasis of medullary thyroid
carcinoma (MTC). Activating mutations in the RET proto-oncogene cause hereditary MTC …

Purpose: Positive results of phase I studies evaluating lenvatinib in solid tumors, including
thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC) …

Purpose Mutations in the RET proto-oncogene and vascular endothelial growth factor
receptor (VEGFR) activity are critical in the pathogenesis of medullary thyroid cancer (MTC) …