[HTML][HTML] Challenges and perspectives in chemical synthesis of highly hydrophobic peptides
LK Mueller, AC Baumruck, H Zhdanova… - … in Bioengineering and …, 2020 - frontiersin.org
Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …
peptides and proteins. Applying the method on hydrophilic structures is usually without …
Crystal structures of agonist-bound human cannabinoid receptor CB1
T Hua, K Vemuri, SP Nikas, RB Laprairie, Y Wu, L Qu… - Nature, 2017 - nature.com
Abstract The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive
constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we …
constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we …
Solution NMR study of integral membrane proteins
CB Kang, Q Li - Current opinion in chemical biology, 2011 - Elsevier
Signals between a cell and its environment are often transmitted through membrane
proteins; therefore, many membrane proteins, including G protein-coupled receptors …
proteins; therefore, many membrane proteins, including G protein-coupled receptors …
Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs
The cannabinoid receptor 2 (CB2) plays an important role in the immune system. Although a
few of GPCRs crystallographic structures have been reported, it is still challenging to obtain …
few of GPCRs crystallographic structures have been reported, it is still challenging to obtain …
Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47 (257)-ligand interaction affording megagonist receptor activation
DW Szymanski, M Papanastasiou… - Journal of proteome …, 2011 - ACS Publications
The lack of experimental characterization of the structures and ligand-binding motifs of
therapeutic G-protein coupled receptors (GPCRs) hampers rational drug discovery. The …
therapeutic G-protein coupled receptors (GPCRs) hampers rational drug discovery. The …
[HTML][HTML] hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation
RW Mercier, Y Pei, L Pandarinathan, DR Janero… - Chemistry & biology, 2010 - cell.com
The human cannabinoid 2 GPCR (hCB2) is a prime therapeutic target. To define potential
cysteine-related binding motifs critical to hCB2-ligand interaction, a library of hCB2 cysteine …
cysteine-related binding motifs critical to hCB2-ligand interaction, a library of hCB2 cysteine …
Three-dimensional quantitative structure–selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2
This paper describes a three-dimensional quantitative structure–selectivity relationships (3D-
QSSR) study for selectivity of a series of ligands for cannabinoid CB1 and CB2 receptors. 3D …
QSSR) study for selectivity of a series of ligands for cannabinoid CB1 and CB2 receptors. 3D …
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies
JHM Lange, MAW van der Neut, HC Wals… - Bioorganic & medicinal …, 2010 - Elsevier
The synthesis and structure–activity relationship studies of imidazoles are described. The
target compounds 6–20 represent a novel chemotype of potent and CB2/CB1 selective …
target compounds 6–20 represent a novel chemotype of potent and CB2/CB1 selective …
Ligand-assisted protein structure (LAPS): an experimental paradigm for characterizing cannabinoid-receptor ligand-binding domains
DR Janero, A Korde, A Makriyannis - Methods in Enzymology, 2017 - Elsevier
Detailed characterization of the ligand-binding motifs and structure–function correlates of the
principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and …
principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and …
Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation
Cannabinoid receptors CB1 and CB2 are a striking class of transmembrane proteins
involved in a high number of important biological processes. In spite of the inherent similarity …
involved in a high number of important biological processes. In spite of the inherent similarity …