Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

Abstract The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive
constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we …

Signals between a cell and its environment are often transmitted through membrane
proteins; therefore, many membrane proteins, including G protein-coupled receptors …

The cannabinoid receptor 2 (CB2) plays an important role in the immune system. Although a
few of GPCRs crystallographic structures have been reported, it is still challenging to obtain …

The lack of experimental characterization of the structures and ligand-binding motifs of
therapeutic G-protein coupled receptors (GPCRs) hampers rational drug discovery. The …

The human cannabinoid 2 GPCR (hCB2) is a prime therapeutic target. To define potential
cysteine-related binding motifs critical to hCB2-ligand interaction, a library of hCB2 cysteine …

This paper describes a three-dimensional quantitative structure–selectivity relationships (3D-
QSSR) study for selectivity of a series of ligands for cannabinoid CB1 and CB2 receptors. 3D …

The synthesis and structure–activity relationship studies of imidazoles are described. The
target compounds 6–20 represent a novel chemotype of potent and CB2/CB1 selective …

Detailed characterization of the ligand-binding motifs and structure–function correlates of the
principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and …

Cannabinoid receptors CB1 and CB2 are a striking class of transmembrane proteins
involved in a high number of important biological processes. In spite of the inherent similarity …