Disulfiram: mechanisms, applications, and challenges
J Lanz, N Biniaz-Harris, M Kuvaldina, S Jain, K Lewis… - Antibiotics, 2023 - mdpi.com
Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …
disorder, other indications have been investigated. This review describes potential clinical …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
The mechanisms of zinc action as a potent anti-viral agent: the clinical therapeutic implication in COVID-19
The pandemic of COVID-19 was caused by a novel coronavirus termed as SARS-CoV2 and
is still ongoing with high morbidity and mortality rates in the whole world. The pathogenesis …
is still ongoing with high morbidity and mortality rates in the whole world. The pathogenesis …
Synthesis, molecular docking and enzyme inhibitory approaches of some new chalcones engrafted pyrazole as potential antialzheimer, antidiabetic and antioxidant …
MS Islam, AM Al-Majid, EN Sholkamy, S Yousuf… - Journal of Molecular …, 2022 - Elsevier
About 25 chalcones engrafted pyrazole scaffold combined with benzothiophene and indole
moieties 5a-y were designed and constructed in two steps using readily available acetyl …
moieties 5a-y were designed and constructed in two steps using readily available acetyl …
Multipotent cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, biological analysis and molecular docking study of benzimidazole-based …
Twenty-four analogues of benzimidazole-based thiazoles (1–24) were synthesized and
assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
Indazole-based Schiff base analogues (1–27) were synthesized by a three-step reaction
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents
With the goal of developing potential cholinesterase pharmaco-therapeutics, a new class of
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …
Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and
evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities …
evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities …
Deciphering the mechanism of gilteritinib overcoming lorlatinib resistance to the double mutant I1171N/F1174I in anaplastic lymphoma kinase
S Liang, Q Wang, X Qi, Y Liu, G Li, S Lu… - Frontiers in Cell and …, 2021 - frontiersin.org
Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple
malignancies, such as non-small cell lung cancer (NSCLC). However, the feasibility of …
malignancies, such as non-small cell lung cancer (NSCLC). However, the feasibility of …
Design, Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Study of Benzimidazole-Based Oxazole Analogues: A Promising …
Alzheimer's disease (AD) is a degenerative neurological condition that severely affects the
elderly and is clinically recognised by a decrease in cognition and memory. The treatment of …
elderly and is clinically recognised by a decrease in cognition and memory. The treatment of …