Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …

The heart is an autoimmune-prone organ. It is crucial for the heart to keep injury-induced
autoimmunity in check to avoid autoimmune-mediated inflammatory disease. However, little …

Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …

Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

The nasal mucosa is often the initial site of respiratory viral infection, replication, and
transmission. Understanding how infection shapes tissue-scale primary and memory …

The immune system plays a critical role during myocardial injury, contributing to repair and
remodeling post myocardial infarction (MI). The myocardial infarct and border zone exhibit …

A challenge in treating cardiac injury is the low heart-specificity of the drugs. Nanostructured
lipid carriers (NLCs) are a relatively new format of lipid nanoparticles which have been used …

Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …