Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

There is now strong evidence of progressive neuropathological processes in bipolar
disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted …

Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …

N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of
multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant …

Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …

Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology
of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ) …

Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Context Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the pathogenesis of bipolar disorder and schizophrenia. It remains unclear …