Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

The past two decades reveal a growing role of continuum biomechanics in understanding
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …

Living soft tissues appear to promote the development and maintenance of a preferred
mechanical state within a defined tolerance around a so-called set point. This phenomenon …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

Controlled tissue growth is essential for multicellular life and requires tight spatiotemporal
control over cell proliferation and differentiation until reaching homeostasis. As cells …

Background The structural elements of the vascular wall, namely, extracellular matrix and
smooth muscle cells (SMC s), contribute to the overall stiffness of the vessel. In this study, we …

Royal jelly (RJ) is a multifunctional bee product with a unique composition and wide-ranging
biological properties, including antioxidant, anti-inflammatory and antiproliferative activities …

Soft biological tissues consist of cells and extracellular matrix (ECM), a network of diverse
proteins, glycoproteins, and glycosaminoglycans that surround the cells. The cells actively …

Abstract Tissue transglutaminase (TG2), a multifunctional protein of the transglutaminase
family, has putative transamidation-independent functions in aging-associated vascular …