Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

In the last decade a tremendous progress has been achieved in understanding the control of
apoptosis by survival and death factors as well as the molecular mechanisms of preparation …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

In the struggle between virus and host, control over the cell's death machinery is crucial for
survival. Viruses are obligatory intracellular parasites and, as such, must modulate apoptotic …

Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas)
induces the formation of the death-inducing signaling complex (DISC). We now show that …

Recent endeavors in the development of adenovirus as a gene vector have focused on the
modification of virus tropism, the accomodation of larger genes, and the increase in stability …

The death receptor Fas is a member of the tumor necrosis factor receptor family; upon
interaction with its ligand it efficiently activates caspases and induces apoptosis. Despite …