The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

The discovery of illisimonin A in 2017 extended the structural repertoire of the Illicium
sesquiterpenoids─ a class of natural products known for their high oxidation levels and …

The Knoevenagel condensation reaction is a prominent organic reaction commonly being
utilized in the total synthesis of natural and biologically potent products as a vital and …

Covering: 2006 to 2015 C–H functionalization remains one of the frontier challenges in
organic chemistry and drives quite an active area of research. It has recently been applied in …

Covering: up to mid-2019 This review highlights the utilization of biomass-derived building
blocks in the total synthesis of natural products. An overview over several renewable …

The Illicium sesquiterpenes are a family of natural products containing over 100 highly
oxidized and structurally complex members, many of which display interesting biological …

Neurodegenerative diseases and spinal cord injury affect approximately 50 million people
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …

Abstract Development of a biologically active secondary metabolite into a useful medicine
requires continuous access to meaningful quantities of material. Although any chemical …

A Robinson annulation, van Leusen homologation, and a desymmetrizing C H oxidation
enabled an enantiospecific synthesis of the neurotrophic natural product jiadifenolide. From …