Purpose Selinexor is a novel XPO1 inhibitor which inhibits the export of tumor suppressor
proteins and oncoprotein mRNAs, leading to cell-cycle arrest and apoptosis in cancer cells …

Chiral drugs usually contain chiral centers, which are present as single enantiomers or
racemates. Compared with achiral drugs, they have significant advantages in safety and …

Responses to therapy often cannot be exclusively predicted by molecular markers, thus
evidencing a critical need to develop tools for better patient selection based on relations …

Extraskeletal myxoid chondrosarcoma (EMC) is a malignant mesenchymal neoplasm of
uncertain differentiation as classified by the WHO Classification of Tumours 2020. Although …

Carfilzomib (CFZ) is a second-generation proteasome inhibitor showing great efficacy in
multiple myeloma treatment, yet its clinical applications for other diseases such as solid …

Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein
that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore …

Abstract Background Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic
transport, is frequently overexpressed in various cancers, driving tumor progression and …

Introduction Soft tissue sarcomas (STS) are a rare and heterogeneous group of tumors. The
role of molecular testing to inform diagnosis, disease prognosis, and therapy has become …

Cancer remains a real and present threat to global health. In the United States, according to
cancer statistics, almost 40% of people will be diagnosed with cancer at some point in their …