Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Traditional cancer therapy methods, especially those directed against specific intracellular
targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity …

The biggest challenge associated with cancer chemotherapy is the development of cross
multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …

The development of multidrug resistance (MDR) in patients suffering cancer remains a
significant clinical challenge, with drug efflux by ABC (ATP-binding cassette) transporters …

Accumulating preclinical and clinical evidence indicates that high degrees of heterogeneity
among malignant cells constitute a considerable obstacle to the success of cancer therapy …

Abstract MicroRNA-200c (miR200c) recently emerged as an important regulator of
tumorigenicity and cancer metastasis; however, its role in regulating multidrug resistance …

Cancer metastasis is the main cause of chemotherapeutic failure. Inhibiting the activity of
matrix metalloproteinases (MMPs) is a common strategy for reducing metastasis. However …

Background: Dual-targeting in cancer treatment by a single drug is an unconventional
approach in relation to drug combinations. The rationale for the development of …

Natural killer lysin (NK-lysin) is a small molecule antimicrobial peptide secreted by natural
killer cells and T lymphocytes. In this study, we characterized a cDNA sequence encoding …

Traditional chemotherapy is one of the main methods of cancer treatment, which is largely
limited by severe side effects and frequent development of multi-drug resistance by cancer …