Circulating testosterone as the hormonal basis of sex differences in athletic performance

DJ Handelsman, AL Hirschberg, S Bermon - Endocrine reviews, 2018 - academic.oup.com
Elite athletic competitions have separate male and female events due to men's physical
advantages in strength, speed, and endurance so that a protected female category with …

Puberty and the human brain: Insights into adolescent development

N Vijayakumar, ZO de Macks, EA Shirtcliff… - … & Biobehavioral Reviews, 2018 - Elsevier
Alongside the exponential flourish of research on age-related trajectories of human brain
development during childhood and adolescence in the past two decades, there has been an …

Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic–hyperinsulinaemic clamp studies

S Cassar, ML Misso, WG Hopkins, CS Shaw… - Human …, 2016 - academic.oup.com
STUDY QUESTION What is the degree of intrinsic insulin resistance (IR) in women with
polycystic ovary syndrome (PCOS) and the relative contribution of BMI to overall IR based …

The regulation of steroid action by sulfation and desulfation

JW Mueller, LC Gilligan, J Idkowiak, W Arlt… - Endocrine …, 2015 - academic.oup.com
Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

Impact of estrogens in males and androgens in females

SR Hammes, ER Levin - The Journal of clinical …, 2019 - Am Soc Clin Investig
Androgens and estrogens are known to be critical regulators of mammalian physiology and
development. While these two classes of steroids share similar structures (in general …

Testosterone replacement therapy and cardiovascular risk

T Gagliano-Jucá, S Basaria - Nature Reviews Cardiology, 2019 - nature.com
Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Hypopituitarism

CE Higham, G Johannsson, SM Shalet - The Lancet, 2016 - thelancet.com
Hypopituitarism refers to deficiency of one or more hormones produced by the anterior
pituitary or released from the posterior pituitary. Hypopituitarism is associated with excess …

Sex steroid actions in male bone

D Vanderschueren, MR Laurent, F Claessens… - Endocrine …, 2014 - academic.oup.com
Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

The art of measuring steroids: principles and practice of current hormonal steroid analysis

SA Wudy, G Schuler, A Sánchez-Guijo… - The Journal of steroid …, 2018 - Elsevier
Steroids are small and highly important structural or signalling molecules in living organisms
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …

From pregnancy to preeclampsia: a key role for estrogens

N Berkane, P Liere, JP Oudinet, A Hertig… - Endocrine …, 2017 - academic.oup.com
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …