High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

The plasma proteome is the ultimate target for biomarker discovery. It stores an endless
amount of information on the pathophysiological status of a living organism, which is …

Background Cancer incidence is higher in men than in women at most shared anatomic
sites for currently unknown reasons. The authors quantified the extent to which behaviors …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Background: Sex dimorphism strongly impacts tumor biology, with most cancers having a
male predominance. Uniquely, thyroid cancer (TC) is the only nonreproductive cancer with …

Age is the most important risk factor for cancer, as cancer incidence and mortality increase
with age. However, how molecular alterations in tumours differ among patients of different …

Background The importance of sex and gender as modulators of disease biology and
treatment outcomes is well known in other disciplines of medicine, such as cardiology, but …