Purpose Sepsis is recognized as a global public health problem, but the proportion due to
hospital-acquired infections remains unclear. We aimed to summarize the epidemiological …

Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Importance Infection is frequent among patients in the intensive care unit (ICU).
Contemporary information about the types of infections, causative pathogens, and outcomes …

Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Background There is a need to better define the epidemiology of sepsis in intensive care
units (ICUs) around the globe. Methods The Intensive Care over Nations (ICON) audit …

Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is
associated with prolonged hospitalization, progression to chronic kidney disease (CKD) …

Extracellular vesicles (EVs) are intercellular communicators with key functions in
physiological and pathological processes and have recently garnered interest because of …

Importance Vasopressin is an alternative to catecholamine vasopressors for patients with
distributive shock—a condition due to excessive vasodilation, most frequently from severe …

Background The prevalence and mortality of sepsis are largely unknown in Turkey, a
country with high antibiotic resistance. A national, multicenter, point-prevalence study was …