The cellular basis of fibrotic tendon healing: challenges and opportunities
AEC Nichols, KT Best, AE Loiselle - Translational Research, 2019 - Elsevier
Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …
resulting in a significant socioeconomic burden and reduced quality of life. Because the …
Growth factor delivery strategies for rotator cuff repair and regeneration
A Prabhath, VN Vernekar, E Sanchez… - International journal of …, 2018 - Elsevier
The high incidence of degenerative tears and prevalence of retears (20–95%) after surgical
repair makes rotator cuff injuries a significant health problem. This high retear rate is …
repair makes rotator cuff injuries a significant health problem. This high retear rate is …
Growth and mechanobiology of the tendon-bone enthesis
ML Killian - Seminars in cell & developmental biology, 2022 - Elsevier
Tendons are cable-like connective tissues that transfer both active and passive forces
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …
In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair
Rotator cuff tears are common and cause a great deal of lost productivity, pain, and
disability. Tears are typically repaired by suturing the tendon back to its bony attachment …
disability. Tears are typically repaired by suturing the tendon back to its bony attachment …
Chronic degeneration leads to poor healing of repaired massive rotator cuff tears in rats
Background: Chronic rotator cuff tears present a clinical challenge, often with poor outcomes
after surgical repair. Degenerative changes to the muscle, tendon, and bone are thought to …
after surgical repair. Degenerative changes to the muscle, tendon, and bone are thought to …
The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats
Background Chronic massive rotator cuff tears heal poorly and often retear. This study
investigated the effect of adipose-derived stem cells (ADSCs) and transforming growth factor …
investigated the effect of adipose-derived stem cells (ADSCs) and transforming growth factor …
Application of adipose tissue-derived stem cells in a rat rotator cuff repair model
Introduction Healing tissue of the rotator cuff does not regenerate the native enthesis;
fibrovascular scar tissue is formed instead and this has less favourable biomechanical …
fibrovascular scar tissue is formed instead and this has less favourable biomechanical …
Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: Mechanical strain amplitude dependency of fibrosis
The spatiotemporal interaction and constant iterative feedback between fibroblasts,
extracellular matrix, and environmental cues are central for investigating the fibroblast …
extracellular matrix, and environmental cues are central for investigating the fibroblast …
Development of a mouse model of supraspinatus tendon insertion site healing
Supraspinatus (SS) tendon tears are common musculoskeletal injuries whose surgical
repair exhibits the highest incidence of re‐tear of any tendon. Development of therapeutics …
repair exhibits the highest incidence of re‐tear of any tendon. Development of therapeutics …
Sclerostin antibody treatment enhances rotator cuff tendon-to-bone healing in an animal model
SA Shah, I Kormpakis, N Havlioglu, MS Ominsky… - JBJS, 2017 - journals.lww.com
Background: Rotator cuff tears are a common source of pain and disability, and poor healing
after repair leads to high retear rates. Bone loss in the humeral head before and after repair …
after repair leads to high retear rates. Bone loss in the humeral head before and after repair …