The cellular basis of fibrotic tendon healing: challenges and opportunities

AEC Nichols, KT Best, AE Loiselle - Translational Research, 2019 - Elsevier
Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Growth factor delivery strategies for rotator cuff repair and regeneration

A Prabhath, VN Vernekar, E Sanchez… - International journal of …, 2018 - Elsevier
The high incidence of degenerative tears and prevalence of retears (20–95%) after surgical
repair makes rotator cuff injuries a significant health problem. This high retear rate is …

Growth and mechanobiology of the tendon-bone enthesis

ML Killian - Seminars in cell & developmental biology, 2022 - Elsevier
Tendons are cable-like connective tissues that transfer both active and passive forces
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …

In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair

J Lipner, H Shen, L Cavinatto, W Liu… - … Engineering Part A, 2015 - liebertpub.com
Rotator cuff tears are common and cause a great deal of lost productivity, pain, and
disability. Tears are typically repaired by suturing the tendon back to its bony attachment …

Chronic degeneration leads to poor healing of repaired massive rotator cuff tears in rats

ML Killian, LM Cavinatto, SR Ward… - … American journal of …, 2015 - journals.sagepub.com
Background: Chronic rotator cuff tears present a clinical challenge, often with poor outcomes
after surgical repair. Degenerative changes to the muscle, tendon, and bone are thought to …

The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats

BB Rothrauff, CA Smith, GA Ferrer, JV Novaretti… - Journal of shoulder and …, 2019 - Elsevier
Background Chronic massive rotator cuff tears heal poorly and often retear. This study
investigated the effect of adipose-derived stem cells (ADSCs) and transforming growth factor …

Application of adipose tissue-derived stem cells in a rat rotator cuff repair model

MV Mora, SA Antuña, MG Arranz, MT Carrascal… - Injury, 2014 - Elsevier
Introduction Healing tissue of the rotator cuff does not regenerate the native enthesis;
fibrovascular scar tissue is formed instead and this has less favourable biomechanical …

Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: Mechanical strain amplitude dependency of fibrosis

D Jacho, A Rabino, R Garcia-Mata, E Yildirim-Ayan - Scientific Reports, 2022 - nature.com
The spatiotemporal interaction and constant iterative feedback between fibroblasts,
extracellular matrix, and environmental cues are central for investigating the fibroblast …

Development of a mouse model of supraspinatus tendon insertion site healing

R Bell, P Taub, P Cagle, EL Flatow… - Journal of …, 2015 - Wiley Online Library
Supraspinatus (SS) tendon tears are common musculoskeletal injuries whose surgical
repair exhibits the highest incidence of re‐tear of any tendon. Development of therapeutics …

Sclerostin antibody treatment enhances rotator cuff tendon-to-bone healing in an animal model

SA Shah, I Kormpakis, N Havlioglu, MS Ominsky… - JBJS, 2017 - journals.lww.com
Background: Rotator cuff tears are a common source of pain and disability, and poor healing
after repair leads to high retear rates. Bone loss in the humeral head before and after repair …