Two phylogenetically and structurally distinct groups of proteins regulate stress induced
intrinsic apoptosis, the programmed disassembly of cells. Together they form the B cell …

Apoptosis is a biological process that removes damaged, excess or infected cells through a
genetically controlled mechanism. This process plays a crucial role in organismal …

The roles of chance, contingency, and necessity in evolution are unresolved because they
have never been assessed in a single system or on timescales relevant to historical …

Cells need to sense stresses to initiate the execution of the dormant cell death program.
Since the discovery of the first BH3‐only protein Bad, BH3‐only proteins have been …

B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which
indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role …

Herpesviruses are known to acquire several genes from their hosts during evolution. We
found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and …

Lots of cell death initiator and effector molecules, signalling pathways and subcellular sites
have been identified as key mediators in both cell death processes in cancer. The …

Translationally Controlled Tumor Protein (TCTP) serves as a pro-survival factor in tumor
cells, inhibiting the mitochondrial apoptosis pathway by enhancing the function of anti …

Our previous pre-clinical work defined BCL-2 induction as a critical component of the
adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar …

Introduction: Mitochondria play important roles in regulating multiple biological processes
and signalling pathways in eukaryotic cells, and mitochondrial dysfunction may result in a …