The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

Cardiac imaging to evaluate left ventricular diastolic function

FA Flachskampf, T Biering-Sørensen… - JACC: Cardiovascular …, 2015 - jacc.org
Left ventricular diastolic dysfunction in clinical practice is generally diagnosed by imaging.
Recognition of heart failure with preserved ejection fraction has increased interest in the …

Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction: a National Heart, Lung, and Blood …

LEJ Thomson, J Wei, M Agarwal… - Circulation …, 2015 - Am Heart Assoc
Background—Women with signs and symptoms of ischemia and no obstructive coronary
artery disease often have coronary microvascular dysfunction (CMD), diagnosed by invasive …

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial …

CN Bairey Merz, EM Handberg, CL Shufelt… - European heart …, 2016 - academic.oup.com
Aims The mechanistic basis of the symptoms and signs of myocardial ischaemia in patients
without obstructive coronary artery disease (CAD) and evidence of coronary microvascular …

Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization

F Crea, CN Bairey Merz, JF Beltrame… - European heart …, 2019 - academic.oup.com
Persistence or recurrence of angina after a percutaneous coronary intervention (PCI) may
affect about 20–40% of patients during short–medium-term follow-up. This appears to be …

Sex differences in cardiovascular aging and heart failure

A Oneglia, MD Nelson, CNB Merz - Current heart failure reports, 2020 - Springer
Abstract Purpose of the Review This review summarizes sex-related changes in the heart
and vasculature that occur with aging, both in the presence and absence of cardiovascular …

Coronary microvascular dysfunction and heart failure with preserved ejection fraction as female-pattern cardiovascular disease: the chicken or the egg?

MD Nelson, J Wei, CN Bairey Merz - European heart journal, 2018 - academic.oup.com
Coronary microvascular dysfunction and heart failure with preserved ejection fraction as
female-pattern cardiovascular disease: Page 1 …

Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women

J Wei, MD Nelson, EW Szczepaniak… - American Journal …, 2016 - journals.physiology.org
Women with coronary microvascular dysfunction (CMD) and no obstructive coronary artery
disease (CAD) have increased rates of heart failure with preserved ejection fraction …

Cardiovascular magnetic resonance for the diagnosis and management of heart failure with preserved ejection fraction

A Barison, A Aimo, G Todiere, C Grigoratos… - Heart failure …, 2022 - Springer
Heart failure with preserved ejection fraction (HFpEF) is characterized by an impaired
ventricular filling resulting in the development of dyspnea and other HF symptoms. Even …

Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome …

CA Rambarat, IY Elgendy, EM Handberg… - International journal of …, 2019 - Elsevier
Background In a prior trial of late sodium channel inhibition (ranolazine) among symptomatic
subjects without obstructive coronary artery disease (CAD) and limited myocardial perfusion …