Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L Xia, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites

SV Siegel, H Trimarsanto, R Amato, K Murie… - Nature …, 2024 - nature.com
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …

Resolving the cause of recurrent Plasmodium vivax malaria probabilistically

AR Taylor, JA Watson, CS Chu, K Puaprasert… - Nature …, 2019 - nature.com
Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …

Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

JM Sá, SR Kaslow, RR Moraes Barros… - Nature …, 2019 - nature.com
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ)
against blood-stage parasites plus primaquine against dormant liver-stage forms …

Recrudescence, Reinfection, or Relapse? A More Rigorous Framework to Assess Chloroquine Efficacy for Plasmodium vivax Malaria

J Popovici, L Pierce-Friedrich, S Kim… - The Journal of …, 2019 - academic.oup.com
Background Plasmodium vivax resistance to chloroquine (CQ) has been reported
worldwide, although the World Health Organization clinical drug efficacy studies protocol …

Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax transcripts

B Hazzard, JM Sá, AC Ellis, TV Pascini… - PLOS Neglected …, 2022 - journals.plos.org
Plasmodium vivax infections often consist of heterogenous populations of parasites at
different developmental stages and with distinct transcriptional profiles, which complicates …

Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion

C Roesch, J Popovici, S Bin, V Run, S Kim… - PLoS neglected …, 2018 - journals.plos.org
The interaction between Plasmodium vivax Duffy binding protein (PvDBP) and Duffy antigen
receptor for chemokines (DARC) has been described as critical for the invasion of human …

Population genomics identifies a distinct Plasmodium vivax population on the China-Myanmar border of Southeast Asia

AM Brashear, Q Fan, Y Hu, Y Li, Y Zhao… - PLoS Neglected …, 2020 - journals.plos.org
Plasmodium vivax has become the predominant malaria parasite and a major challenge for
malaria elimination in the Greater Mekong Subregion (GMS). Yet, our knowledge about the …