Bile acid (BA) species and the gut microbiota (GM) contribute to intestinal mucosa
homeostasis. BAs shape the GM and, conversely, intestinal bacteria with bile salt hydrolase …

Exposure to plant toxins or microbiota that are able to digest common food ingredients to
toxic structures might be responsible for biliary atresia (BA). An isoflavonoid, biliatresone is …

Background & Aims Hepatocellular carcinoma (HCC) is a male-dominant disease, but
targeted sex hormone therapies have not been successful. Bile acids are a potential liver …

Deletion of the nuclear hormone receptor small heterodimer partner (Shp) ameliorates the
development of obesity and nonalcoholic steatohepatitis (NASH) in mice. Liver-specific SHP …

Hepatocellular carcinoma (HCC) is the terminal phase of multiple chronic liver diseases,
and evidence supports chronic uncontrollable inflammation being one of the potential …

Bile acids serve as endogenous ligands for nuclear and cell membrane receptors and play a
crucial role in bile acid and lipid metabolism. These detergent-like compounds promote bile …

Background Fetal growth restriction (FGR) increases risk for development of obesity and
type 2 diabetes. Using a mouse model of FGR, we tested whether metabolic outcomes were …

N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and
lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in …

Aspirin is a non-steroidal, anti-inflammatory drug often used long term. However, long-term
or large doses will cause gastrointestinal adverse reactions. To explore the mechanism of …

The abundance of specific gut microorganisms is strongly associated with the
concentrations of microbially modified bile acids. This study aimed to investigate the …