When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …

Deep vein thrombosis (DVT) is a major origin of morbidity and mortality. While DVT has long
been considered as blood coagulation disorder, several recent lines of evidence …

Deep venous thrombosis is a frequent, multifactorial disease and a leading cause of
morbidity and mortality. Most of the time deep venous thrombosis is triggered by the …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

Endothelial secretion of von Willebrand factor (VWF) from intracellular organelles known as
Weibel-Palade bodies (WPBs) is required for platelet adhesion to the injured vessel wall …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Structural specialisations enable von Willebrand factor (VWF) to assemble during
biosynthesis into helical tubules in Weibel‐Palade bodies (WPB). Specialisations include a …

The von Willebrand factor (VWF) synthesized and secreted by endothelial cells is central to
hemostasis and thrombosis, providing a multifunctional adhesive platform that brings …

Weibel-Palade bodies (WPBs) are secretory organelles used for post-synthesis storage in
endothelial cells that can, very rapidly, be triggered to release their contents. They carry a …