In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

Serine proteases such as trypsin and mast cell tryptase cleave protease-activated receptor-2
(PAR 2) at R 36↓ S 37 and reveal a tethered ligand that excites nociceptors, causing …

Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …

Although it has been known since the 1960s that trypsin and chymotrypsin can mimic
hormone action in tissues, it took until the 1990s to discover that serine proteinases can …

Enhancing the oral bioavailability of peptide drug leads is a major challenge in drug design.
As such, methods to address this challenge are highly sought after by the pharmaceutical …

G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential
(TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …

Macrophages play a central role in dictating the tissue response to infection and
orchestrating subsequent repair of the damage. In this context, macrophages residing in the …

While proteases are essential in gastrointestinal physiology, accumulating evidence
indicates that dysregulated proteolysis plays a pivotal role in the pathophysiology of …