The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

Transgenerational effects have wide-ranging implications for human health, biological
adaptation, and evolution; however, their mechanisms and biology remain poorly …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

Due to differences in anatomy, primary rectal and colon cancer require different staging
procedures, different neo-adjuvant treatment and different surgical approaches. For …

It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …

This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …